Before it is calorie restriction. Some animal studies conducted over the past 20 years have shown up to a 40% increase in maximum life span. CR also provides numerous secondary health benefits, such as a greatly lowered risk for most degenerative conditions of aging.
Since the discovery of the longevity genes- SIR genes or the 'silent information regulator' gene a decade ago, its only now that David Sinclair of Harvard School of Medicine has found a way to activate these genes resulting in production of an enzyme deacetylase.
http://www.supercentenarian.com/archive/longevity-genes.html
Deacetylase would remove acetyl group from histones in the chromosome resulting in ”choking off” of the chromosome making it 'silent '. It is in this state that life span is increased.
How can SIR genes be activated ? Resveratrol , a molecule that can be found in grapes, blue berries and other plants is the key. Must we then be drinking red wine? Sinclaire admits we may start drinking 'few bottles' a day but we will not have the desired effect!
Sinclair is now trying to develop a drug that would do the job. Other than that, no caloric restriction is necessary. NO DIETING NEEDED!! Coming in the next 5 years?
http://www.lewrockwell.com/sardi/sardi25.html
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